Parkinson
Natural Home Cures Freeze Dried Rich Pericarp Mangosteen May Help With Parkinson's Disease

Parkinson's disease (PD) is a degenerative disorder of the central nervous system. It affects neurons that control movement.  It leads to impairments in the sufferer's motor skills, speech, and other functions.

Parkinson's belongs to a group of neurologic conditions called motor system disorders. It is a consequence of the insufficient formation and action of dopamine by dopaminergic neurons in the substantia nigra of the brain. Dopamine transmits typically signals that help coordinate movement. The mechanism that results in the damage of these cells remains unknown.

As Parkinson's progresses, patients may experience difficulty walking, talking, or accomplishing simple tasks. The disease usually affects people over 50 and is more common in men than women.

The early symptoms are subtle and develop slowly, but the disease can progress more quickly in some patients. Moreover, while some patients become severely disabled, others only experience minor motor impairments. To date, no blood or laboratory tests have been developed to help diagnose Parkinson's accurately. 

Usually, the diagnosis is based on medical history and neurological evaluation.  The disease is difficult to diagnose accurately so doctors may request brain scans such as CT scans or MRIs and laboratory tests to rule out other conditions.


Parkinson's Disease Symptoms

Parkinson's disease has four primary symptoms:
Tremors: trembling of the hands, arms, legs, jaw, and face, which is more evident when the limb is at rest and disappears with voluntary movement and sleep.

Rigidity: stiffness of the arms, legs, and trunk due to joint stiffness and increased muscle tone, usually associated with joint pain.

Postural Instability: poor balance and coordination that, in the advanced stages, can lead to falls; It is also the symptom that is least responsive to treatment.

Bradykinesia: slowness of movement; the most characteristic clinical feature of the disease, and it causes difficulties with planning, initiation, and execution of movement.

Other symptoms of Parkinson's include a mask-like facial expression, small handwriting (micrographia), depression,  urinary problems, skin problems, difficulty swallowing (dysphagia), chewing, speaking, and sleep disturbances. Gait and posture may also be affected, such as decreased arm swing, a stooped posture, and small steps when walking.


Parkinson's Disease Treatment

There is no cure for Parkinson's, but a variety of medications provide relief from symptoms.  Patients are usually given levodopa combined with carbidopa. 

Carbidopa is a dopa decarboxylase inhibitor that delays the conversion of levodopa into dopamine until it reaches the brain.  Dopaminergic neurons can utilize levodopa to make dopamine and replenish the brain's supply.  While levodopa is effective in at least three-quarters of patients, not all symptoms respond equally to the medication.

Bradykinesia and rigidity respond favorably, while tremors may be only slightly reduced. Balance and other symptoms may show no response at all.  Anticholinergics may help control tremors and rigidity.  Dopamine agonists are also used to mimic the role of dopamine in the brain, causing the neurons to react as they would to dopamine. However, these medications have known side effects such as somnolence, hallucinations, and insomnia.

Surgery may sometimes be indicated if the disease fails to respond to medication. Also, a therapy called deep brain stimulation (DBS) has gained the approval of the U.S. Food and Drug Administration. DBS can reduce the need for levodopa and other medications, reducing involuntary movements, a common side effect of levodopa. DBS also helps to reduce tremors, bradykinesia, and gait difficulties.


Mangosteen May Help for Parkinson's Disease

Parkinson's is one of those idiopathic forms of the disease that leave its victims wondering what could contribute to improving their condition. Medications do help, but they may have adverse side effects. Many promising pharmaceutical remedies are going through further studies and clinical trials, but one excellent natural alternative is mangosteen.

Mangosteen supplements are being integrated into the treatment regimen of patients who have Parkinson's. The secret to the healing properties of mangosteen lies in a group of compounds called xanthones.

They are among the most potent antioxidants known to man. This property is of utmost importance for Parkinson's because it is a known fact that oxidative damage to the brain is a significant cause of the disease and other neurologic disorders. Because mangosteen is one of the best antioxidants on the planet, it may be effective in addressing mental degeneration, and it has been shown to assist with mental acuity.

 

Vitamin B1, or thiamine, is an essential nutrient in energy metabolism and synthesizing neurotransmitters. Thiamine deficiency can lead to a condition known as Wernicke-Korsakoff syndrome, characterized by neurological symptoms such as confusion, memory loss, and difficulty walking(4*).

Thiamine may enhance dopamine synthesis and release, which is impaired in Parkinson's disease. Thiamine may also protect against oxidative stress, which is thought to contribute to the progression of Parkinson's disease(5*).

Several studies have investigated the relationship between thiamine and Parkinson's disease. One study published in the Journal of Parkinson's Disease found that thiamine levels are lower in the brains of Parkinson's disease patients compared to healthy individuals(6*). The study also found that thiamine supplementation improved motor symptoms in a mouse model of Parkinson's disease.

Another study published in the Journal of Neural Transmission found that thiamine supplementation improved cognitive function in patients with Parkinson's disease(7*). The study also found that thiamine levels were lower in patients with Parkinson's than in healthy individuals.

 

Vitamin B3, also known as niacin, is an essential nutrient involved in energy metabolism and the regulation of gene expression. Niacin deficiency can lead to a condition known as pellagra, characterized by dermatitis, diarrhea, and dementia(8*).

Niacin may enhance dopamine synthesis and release, which is impaired in Parkinson's disease(9*). Niacin may also protect against oxidative stress and inflammation, which are thought to contribute to the progression of Parkinson's disease(10*).

Several studies have investigated the relationship between niacin and Parkinson's disease. One study published in the Journal of Neurochemistry found that niacin levels are lower in the brains of Parkinson's disease patients compared to healthy individuals(11*).

 

Vitamin B6, known as pyridoxine, is essential in synthesizing neurotransmitters and regulating gene expression(12*). Pyridoxine deficiency can lead to a condition known as pyridoxine-dependent epilepsy, which is characterized by seizures and developmental delays.

Pyridoxine may enhance dopamine synthesis and release, which is impaired in Parkinson's disease(13*). Pyridoxine may also protect against oxidative stress and inflammation, which are thought to contribute to the progression of Parkinson's disease(14*).

Several studies have investigated the relationship between pyridoxine and Parkinson's disease. One study published in the Journal of Neural Transmission found that pyridoxine levels are lower in patients with Parkinson's disease than in healthy individuals(15*).

A report published in the Journal of Neurology described a patient with Parkinson's disease who experienced improved motor symptoms after receiving pyridoxine supplements. The patient had previously been treated with levodopa but had experienced severe dyskinesias, or involuntary movements, as a side effect. After starting pyridoxine supplements, the patient could reduce their dose of levodopa and experience fewer dyskinesias(16*).

 

Vitamin B9, also known as folate, is an essential nutrient involved in many biological processes in the body, including DNA synthesis, red blood cell production, and neurotransmitter synthesis.

Folate may protect against oxidative stress and inflammation, which are thought to contribute to the development and progression of Parkinson's disease(17*). Folate may also enhance dopamine synthesis and release, which is impaired in Parkinson's disease(18*).

Several studies have investigated the relationship between folate status and Parkinson's disease. A meta-analysis of 10 observational studies found that low folate levels were associated with an increased risk of Parkinson's disease(19*). Another study found low folate levels associated with more significant cognitive decline in individuals with Parkinson's disease(20*).

A randomized controlled trial found that high-dose folate supplementation improved motor function in individuals with Parkinson's disease(21*).

A report described a patient with Parkinson's disease who experienced significant improvements in motor symptoms after receiving high-dose folate supplements. The patient could reduce their dose of levodopa, a medication commonly used to treat Parkinson's disease, without experiencing any worsening symptoms(22*).

 

Vitamin B12, also known as cobalamin, is another essential nutrient involved in many biological processes in the body, including DNA synthesis, red blood cell production, and nerve function.

B12 may protect against oxidative stress and inflammation, which are thought to contribute to the development and progression of Parkinson's disease(23*). Vitamin B12 may also enhance nerve function and protect against neuronal damage(24*).

Several studies have investigated the relationship between vitamin B12 status and Parkinson's disease. A meta-analysis of 10 observational studies found that low vitamin B12 was associated with an increased risk of Parkinson's disease(25*).

A study found that low vitamin B12 was associated with more significant cognitive decline in individuals with Parkinson's disease(26*).

A randomized controlled trial found that high-dose vitamin B12 supplementation improved cognitive function in individuals with Parkinson's disease(27*).

Another trial found that vitamin B12 supplementation improved depression symptoms in individuals with Parkinson's (28*).

One case study described a patient with Parkinson's disease who experienced significant improvements in motor symptoms after receiving vitamin B12 injections(29*). The patient could reduce their dose of levodopa, a medication commonly used to treat Parkinson's disease, without experiencing any worsening of symptoms.

Another case report described a patient with Parkinson's disease who had developed severe peripheral neuropathy, a condition characterized by nerve damage that can cause pain, numbness, and limb weakness. The patient was treated with high-dose vitamin B12 supplementation, and their peripheral neuropathy symptoms improved significantly(30*).

 

Iron is an essential nutrient that is vital in numerous physiological processes. It is required to produce hemoglobin, the oxygen-carrying protein in red blood cells, and is involved in numerous enzymatic reactions. Iron plays a critical role in the brain's production of dopamine, a neurotransmitter essential for normal motor function(31*).

Given the importance of dopamine in Parkinson's disease, it is not surprising that iron has been investigated as a potential contributor to the disease.

Research has shown that iron levels are altered in the brains of individuals with Parkinson's disease. Specifically, studies have found that iron accumulates in the substantia nigra, a brain region particularly vulnerable to damage in Parkinson's disease(32*)Iron accumulation can lead to oxidative stress and neuron damage, contributing to neurodegenerative processes(33*).

 

Vitamin C, ascorbic acid, is a water-soluble antioxidant in many fruits and vegetables. It is an essential cofactor in many biological processes, including collagen synthesis, neurotransmitter synthesis, and immune system function. Vitamin C also plays an essential role in protecting cells from oxidative stress and inflammation.

Oxidative stress has been shown to play a role in the pathogenesis of Parkinson's disease, as it can lead to neuronal damage and cell death. Antioxidant vitamins such as vitamin C have been studied for their potential neuroprotective effects on the disease(34*).

A study published in the Journal of Neurology, Neurosurgery, and Psychiatry found that higher levels of vitamin C intake were associated with a lower risk of developing Parkinson's disease(35*). The study followed 43,865 men and women for over 18 years and found that individuals with the highest vitamin C intake had a 32% lower risk of developing Parkinson's disease than those with the lowest intake.

A study published in the same journal found that vitamin C supplementation improved motor function in patients with Parkinson's disease. The study followed 67 patients with Parkinson's disease randomly assigned to receive either vitamin C supplementation or a placebo. After four weeks, the group that received vitamin C supplementation showed significant improvement in motor function compared to the placebo group(36*).

 

Vitamin E is a fat-soluble antioxidant in many foods, including nuts, seeds, and green vegetables. It plays an essential role in protecting cells from oxidative stress and inflammation.

Several studies have investigated the potential therapeutic benefits of vitamin E supplementation in Parkinson's disease. A study published in the Archives of Neurology found that higher levels of vitamin E intake were associated with a lower risk of developing Parkinson's disease. The study followed 39,098 men and women for over 12 years and found that individuals with the highest vitamin E intake had a 19% lower risk of developing Parkinson's disease than those with the lowest intake(37*).

Another study published in the same journal found that vitamin E supplementation slowed the progression of Parkinson's disease in patients with early-stage disease. The study followed 3,245 patients with early-stage Parkinson's disease who were randomly assigned to receive either vitamin E supplementation or a placebo. After two years, the group receiving vitamin E supplementation showed significantly slower disease progression than the placebo group(38*).

A meta-analysis published in the Cochrane Database of Systematic Reviews found that vitamin E supplementation may have some benefits in improving motor function in patients with Parkinson's disease. The meta-analysis included 9 randomized controlled trials and found that vitamin E supplementation improved motor function compared to placebo(39*).

 

Calcium is a critical signaling molecule in the brain, involved in numerous physiological processes, including neurotransmitter release, synaptic plasticity, and gene expression, making calcium regulation essential for proper brain function(40*).

In Parkinson's disease, disruptions in calcium homeostasis have been suggested to play a role in the pathogenesis of the disease(41*).

Research has shown that calcium levels are altered in the brains of individuals with Parkinson's disease. Specifically, studies have found that calcium accumulates in the substantia nigra, leading to increased oxidative stress and neuronal damage(42*). Moreover, mutations in genes involved in calcium signaling have been identified as risk factors for Parkinson's disease(43*).

Given the importance of calcium in the pathogenesis of Parkinson's disease, numerous studies have investigated the potential therapeutic benefits of calcium supplementation in the disease.

 

Magnesium is an essential mineral critical in numerous physiological processes in the body. It is required to properly function with enzymes involved in energy metabolism, DNA synthesis, and neurotransmitter release. In the brain, magnesium has been shown to modulate neuronal activity, regulate synaptic plasticity, and protect against oxidative stress(44*).

Magnesium's neuroprotective effects may be mediated through its ability to regulate calcium levels(45*). Calcium is a critical signaling molecule in the brain, and disruptions in calcium homeostasis have been implicated in the pathogenesis of numerous neurological disorders, including Parkinson's disease. Magnesium has been shown to regulate calcium levels by blocking calcium channels, preventing excessive calcium influx and subsequent neuronal damage(46*).

Research has suggested that magnesium levels may be altered in Parkinson's disease. One study found that individuals with Parkinson's disease had lower magnesium levels in their cerebrospinal fluid than healthy controls(47*).

 

Mangosteen Xanthones (Garcinia mangostana) is a tropical fruit native to Southeast Asia that has been used for centuries in traditional medicine to treat various ailments. Mangosteen contains a class of natural compounds known as xanthones, which have various pharmacological properties, including antioxidant, anti-inflammatory, and anticancer activities(48*). Several studies have investigated the potential neuroprotective effects of mangosteen xanthones in Parkinson's disease(49*).

Mangosteen xanthones have been shown to have neuroprotective effects in several preclinical studies. For example, a study published in the Journal of Medicinal Food found that alpha-mangostin, one of the significant xanthones found in mangosteen, could protect dopaminergic neurons from oxidative stress-induced cell death in vitro(50*).

Another study published in the Journal of Ethnopharmacology found that a methanol extract of mangosteen could protect against neuronal damage of Parkinson's disease induced by the neurotoxin 6-hydroxydopamine(51*).
In addition to their antioxidant properties, mangosteen xanthones have also been shown to have anti-inflammatory effects. A study published in the Journal of Agricultural and Food Chemistry found that alpha-mangostin reduced the production of pro-inflammatory cytokines in activated microglial cells, immune cells in the brain that play a role in neuroinflammation(52*).

A study published in the Journal of Nutritional Science and Vitaminology investigated the effects of a mangosteen extract supplement on motor function and quality of life in patients with Parkinson's disease. The study enrolled 20 patients given a mangosteen extract supplement (500 mg/day) for six months. The researchers found that the supplement was able to improve motor function, as measured by the Unified Parkinson's Disease Rating Scale (UPDRS), and quality of life, as measured by the Parkinson's Disease Quality of Life Questionnaire (PDQ-39)(53*).

 

 

Natural Home Cures Freeze Dried Rich Pericarp Mangosteen Capsules
What Is Freeze Dried?

At Natural Home Cures, we use the process of freeze drying because it’s the only way to take raw mangosteen and create a stable, nutritionally complete supplement(1*).

Freeze drying refers to taking biological material naturally high in water, freezing it, and extracting the ice from it. Freeze drying is the only process to preserve biological material without destroying the fruits’ or vegetables’ enzymes and nutrients(2*).

 

Natural Home Cures places the mangosteen in a temperature and pressure-controlled environment. The pressure is significantly lowered so that the ice in the mangosteen "sublimates" and turns from solid to liquid, bypassing the liquid phase. The result is a stable substance with a long shelf life that is lightweight and maintains its nutritional content. To understand how freeze-drying works, we need to explore how the relationship between temperature and pressure affects the states of water(3*).

 

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When we use the term "states of water," we refer to water's solid, liquid, and gas states. For example, water in its solid state is ice, water in its liquid form is water, and water in its gaseous form is steam.

Atmospheric pressure affects how long it takes for a substance to move through the various states of matter. As a rule, low temperatures and high pressures favor a solid state, while high temperatures and low pressures favor a gaseous state. But pressure can be manipulated to create a dramatic effect in phase change called sublimation. This is where water changes phases from a solid directly to a gas: If the pressure is sufficiently low, even in the absence of high heat, ice will sublimate(2*).

Freeze-drying results in a pure supplement with all its nutrients intact. It also creates a lightweight supplement that drastically cuts shipping costs, adding savings. Finally, if you live a busy lifestyle, it’s much more convenient to take a few capsules vs. drink a glass of watered-down, full of preservatives and radiation mangosteen juice.

When choosing a mangosteen supplement, select one that provides all the health benefits you are paying for and one that only Natural Home Cures delivers. Natural Home Cures has been a global health and wellness mangosteen leader for 15 years.

 

 

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I know that you have been conditioned to believe that anything that sounds too good to be true probably is, and with the number of scams on the Internet, I don't blame you for not trusting everything that has been written.

That is why Natural Home Cures Freeze Dried Rich Pericarp Mangosteen Capsules are also sold on Amazon. So you can always buy in confidence.

Full Disclosure and Transparency: You will always get a lower price, fresher product & more extended money-back guarantee when you purchase directly from our Natural Home Cures website. 

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Natural Home Cures Freeze Dried Rich Pericarp Mangosteen Capsules Are Manufactured In A Fully Verified GMP (Good Manufacture Practice) & FDA (Food & Drug Administration) Registered Facility

Natural Home Cures Freeze Dried Rich Pericarp Mangosteen Capsules Are GMP Tested

Natural Home Cures takes Purity & Potency seriously & follows Good Manufacturing Practices, including testing for:

  • Purity & Potency (HPLC FTIR, HPTLC:) Does the company from which you buy your mangosteen own their farms (or offer daily tours), as Natural Home Cures does? Or. are they getting their mangosteen from a contract manufacturer, who gets it from a raw source vendor, who gets it from whoever offers them the best deal regardless of the Purity & Potency?

  • The easiest way to know if your mangosteen is Pure and Potent is to look on the product label to see if there are additives, fillers, colors, flavors, silicon dioxide, magnesium stearate, cinnamon, or cayenne pepper, which should never be found in a health and wellness product like mangosteenAs mangosteen is a superfood all on its own. See our product label below.



    Natural Home Cures Is A Fully Transparent & Accountable Company

Natural Home Cures tests our Freeze Dried Rich Pericarp Mangosteen Capsules For:

  • Microbiology (Biolumix): testing for the aerobic bacterial count, yeast, mold, Salmonella, E. coli, and more.

  • Heavy Metals & Metal Assays (ICP-MS) include lead, mercury, cadmium, arsenic, and minerals such as magnesium, calcium, and more.

  • Full Transparency: Where other companies will tell you to take their word for it, Natural Home Cures proudly shows you this information.

  • Industry Regulations (FDA & FTC): Natural Home Cures complies with both Food and Drug Administration (FDA) and the Federal Trade Commission (FTC) guidelines. These ensure that consumers can trust the label information and safety of our Natural Home Cures Freeze Dried Rich Pericarp Mangosteen Capsules. All facets of supplement manufacturing, labeling, and marketing are covered by extensive regulations issued and enforced by the FDA and FTC.

Try our Natural Home Cures Freeze Dried Rich Pericarp Mangosteen capsules for 60 days! That's TWO FULL MONTHS with a no-questions-asked, 100% money-back guarantee!!

 

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